Burton Lee, Executive Vice-President, Lee Scientific, Inc., St. Louis, MO 314-968-1091
"As a bulk manufacturer of enzymes, antigens and related proteins we decided to try a novel 36-cm SPC to address our growing production needs. What is exciting about this innovative column is that we were able to shorten our processing time almost 4 fold with an added benefit of improved quality and yield of our eluted Alkaline Phosphatase and Lactate Dehydrogenase. The payoff was an improved bottom line and a very short payoff of our new column. Since 1999  we acquired several more prep-size SPC".

T. Richard Leary, Ph.D., Director of Process Engineering, Fresenius Hemotechnology, Inc. (former Cypress, Inc.), Redmond, WA 425-497-1197
"Our experience with SPC generally confirms theoretical benefits of this novel design. The elution peaks are narrow and there is less tailing than in the "conventional" columns. We really appreciate ruggedness as well as consistency of volume and performance crucial in our clinical production and validation work". 

Fred Drewe, Ph.D., Drewe & Associates, Austin, TX 512-263-2960
"I would recommend SPC to all of my clients. The best points about SPC is how fast the whole process runs and the operating ruggedness. Processes have never been this fast with other systems and allow a much faster cycle time for a column run. Production personnel really appreciate when different operators, on different days and with different batches, can consistently reproduce the performance". 

Leslie Carvalho, Vice President, STC Laboratories Inc. Winnipeg, Manitoba 204-944-6700
"In our hands, Side Pack Columns proved to be superior to "conventional" columns, by the design and workmanship. Our Process Development and Manufacturing switched to SPC columns due to convenience and reproducibility of packing and operation". 

Dev Baines, Ph.D., Affinity Chromatography Ltd., Cambridge, UK , 44 (0) 12 23 27 71 92
"ACL develops and manufactures robust affinity adsorbents for large-scale chromatography. We routinely use Six-Loader SPC to screen adsorbents as well to optimize separation conditions. The information derived is then confirmed on the larger scale SPC. Of particular value is the ease of reproducible packing of the SPC columns". 

Peter Grandics, Ph.D., President of Sterogene, Inc. (Carlsbad, CA), 800-535-2284
According to Dr. Grandics,  Sterogene was developing a large-scale capture step using its proprietary sorbents and different column hardware.  The equilibration cycle on SPC (0.1- and 1-L sizes) appeared to be  3-4 fold shorter compared to the "conventional" hardware.  Moreover,  conventional columns still had "black nail rims" around the O-rings even after the specified UV base line was reached.

Peter R. Levison, Anne K. Hopkins, Prit Hathi, Whatman International Ltd. "Influence of column design on process-scale ion-exchange chromatography", Journal of Chromatography A, 865 (1999) 3-12.  In this paper, SPC (early prototype,16-L)  was compared to the 24-L "conventional" column (IsoPak) and found to be very similar  in most performance characteristics (packing accuracy, back-pressure, resolution, etc).